• Always book a direct, non-stop flight whenever possible
• Check airline regulations 
• If you want to take your pet along on an airplane, it is essential to check with your particular airline for regulations. Small animals are sometimes allowed in an under-seat carrier in the cabin. However, reserving a spot is essential since airlines only allow a few pets per flight.
•  Most airlines also require a veterinarian-issued health certificate dated a certain number of days prior to travel. Be sure to plan in advance so you can get an appointment with a veterinarian who can issue such a certificate.
•     If your pet will be traveling in the cargo hold of the plane, time of year and weather must be considered, The Federal Animal Welfare Act places temperature restrictions that determine whether a pet will be accepted on a flight.
• Once your airline reservations are made, your planning is not yet complete. Airlines also have spefcfic guidelines for approved transport crates. These guidelines include size, latch, labeling and airflow. Check with your airline for these specific guidelines and recommendations on where to purchase acceptable crates.
• Talk to your Veterinarian
• Talk to your veterinarian regarding recommended feeding instructions. Often air travel on an empty stomach will make a more comfortable trip for your pet.
• Day of Travel
• On the day of travel, be sure to exercise your pet before placing him or her in the crate.
• If possible, check your pet as late as the airline will allow to reduce the time spent in the crate.

With heightened security these days, be sure to confirm the pet rules with your airline every time you fly since air regulations are changing constantly.